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the effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia年龄对炎症的影响,coagulation-fibrinolysis反应病人住院肺炎.pdf

发布:2017-09-11约7.76万字共11页下载文档
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The Effects of Age on Inflammatory and Coagulation- Fibrinolysis Response in Patients Hospitalized for Pneumonia 1,2 1,2 3 3 1,2 4 Sachin Kale , Sachin Yende *, Lan Kong , Amy Perkins , John A. Kellum , Anne B. Newman , Abbe N. Vallejo5, Derek C. Angus1,2, for the GenIMS Investigators 1The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 5 Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Objective: To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly. Methods: In an observational cohort of subjects with community-acquired pneumonia (CAP) recruited from emergency departments (ED) in 28 hospitals, we divided subjects into 5 age groups (,50, 51–64, 65–74, 75–84, and $85). We measured circulating levels of inflammatory (TNF, IL-6, and IL-10), hemostasis (D-dimer, Factor IX, thrombin-antithrombin complex, antithrombin and plasminogen-activator inhibitor-1), and cell-surface markers (TLR-2, TLR-4, and HLA-DR) during the first week of hospitalization an
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