the effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia年龄对炎症的影响,coagulation-fibrinolysis反应病人住院肺炎.pdf
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The Effects of Age on Inflammatory and Coagulation-
Fibrinolysis Response in Patients Hospitalized for
Pneumonia
1,2 1,2 3 3 1,2 4
Sachin Kale , Sachin Yende *, Lan Kong , Amy Perkins , John A. Kellum , Anne B. Newman , Abbe N.
Vallejo5, Derek C. Angus1,2, for the GenIMS Investigators
1The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of
America, 2 Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Department of Biostatistics, Graduate
School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department of Epidemiology, Graduate School of Public Health,
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 5 Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh,
Pittsburgh, Pennsylvania, United States of America
Abstract
Objective: To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by
age and whether these differences explain higher mortality in the elderly.
Methods: In an observational cohort of subjects with community-acquired pneumonia (CAP) recruited from emergency
departments (ED) in 28 hospitals, we divided subjects into 5 age groups (,50, 51–64, 65–74, 75–84, and $85). We measured
circulating levels of inflammatory (TNF, IL-6, and IL-10), hemostasis (D-dimer, Factor IX, thrombin-antithrombin complex,
antithrombin and plasminogen-activator inhibitor-1), and cell-surface markers (TLR-2, TLR-4, and HLA-DR) during the first
week of hospitalization an
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