DC_CIK细胞联合化疗治疗晚期非小细胞肺癌的临床探讨_李冰.pdf

35 Vol35, No1 2011 1 Jan2011 4 HEI LONG JIANG MED ICAL JOURNAL DC- CIK 李 冰, 郑秋红 (, 350014) : 目的 探讨树突状细胞- 细胞因子诱导杀伤细胞( DC- CIK)过继免疫治疗联合化疗晚期非小细 胞 癌的临床疗效及相关因素对生存预后的影响方法 回顾性分析 0例行 DC- CIK 联合化疗的初治 晚期非小细胞 癌, 并按 11配对选择同期单独行化疗的 0例初治晚期非小细胞 癌作为对照对两组 的疗效进行生存分析, 比较两组的毒性反应, 并用 Log- rank检验比较临床因素对生存的影响结果 DC 2 - CIK 治疗组 癌患者的中位生存期明显高于化疗组( 123 个月 VS 35 个月), 差异有统计学意义 ( = 42295, P = 0000)在 DC- CIK治疗组中, 患者的性别体重下降程度KPS 评分转移数目, 及是否发生 肝转移显著影响 DC- CIK 的生存预后, 差异有统计学意义结论 DC- CIK 细胞联合化疗可以明显延长 晚期非小细胞 癌的生存期 : 非小细胞 癌; 树突状细胞- 细胞因子诱导的杀伤细胞; 预后 do:i 103969/ jissn1004- 5 5201101002 : 3206 : R 3051 : A Clinical R esearch of Advanced N on- sm all Cell Lung Cancer Patients Treated w ith DC - CIK Cell Combined w ith Chemotherapy LI Bing, ZHENG Q iu- hong (TheTeachingHosp ital of FuJianMedical University, The SurgicalOncology Laboratory Depart ent of FuJianTu orHosp ital, Fuzhou 350014, CH INA) Abstract Objective To evaluate the effects of Dendritic cells- Cytok ine induced k iller cells( DC- CIK cells) a doptive mi munotherapy combined w ith chemotherapy and correlated the clinical factors on the prognosis of ad vanced non- small cell lung cancer( NSCLC). M ethods W e retrospectively analyzed 0 previously untreated pa tients of advanced non- small cell lung cancer(NSCLC) treatedw ith chemotherapy combinedw ith DC- CIK and choose 0 paients at the same period as control treated only w ith chemotherapyTo compare the efficacy of the tw o group in survival analysis, the toxicity of the two groupw as observ