血清胱抑素C测定在糖尿病及高血压肾病早期诊断的临床意义.pdf

2012 27 West China Medical Journal Vol.27 No.6 Jun. 2012 845 C C Cys-C 2007 7 2009 3 89 76 Cys-C BUNScrUAERUAER Cys-C Cys-CUAER P 0.01BUNScr P 0.05, Cys-C UAER BUNScr r=0.9360.6920.653 P 0.01) BUNScr Cys-C / C A Clinical Significance of Serum Cystatin C Determination in the Early Diagnosis of Diabetic and Hypertensive NephropathyLIANG Hong-feng, YAO Jin-xiu, TAN Guo-ju, HUANG Xiao-yu. Yangjing Peoples Hospital, Yangjiang, Guangdong 529500, P. R. China Corresponding author: YAO Jin-xiu, E-mail: yjx_886@163.com Abstract Objective To investigate the clinical signifi cance of serum cystatin C (Cys-C) determination in early screening and monitoring primary chronic kidney diseases (CKD) induced by hypertension and diabetes. MethodsWe collected the serum of 89 patients with diabetes-induced and 76 patients with hypertension induced CKDs treated between July 2007 and March 2009. The concentrations of Cys-C, blood urea nitrogen (BUN), serum creatinine (Scr), and urinary albumin excretion rate (UAER) in the patients were detected by particle enhanced turbidimetric immunoassay. Then, based on UAER, we analyzed the relationship between Cys-C and traditional parameters in renal function injury. Results The concentrations of serum Cys-C and UAER in early nephropathy patients were signifi cantly different from the normal controls (P 0.01), while there was no statistical difference in traditional parameters like BUN and Scr (P 0.05). For patients with intermediate or advanced renal injury, the concentration of serum Cys-C was signifi cantly correlated with