temporal sequence of visuo-auditory interaction in multiple areas of the guinea pig visual cortexvisuo-auditory互动的时间序列在多个领域的豚鼠视觉皮质.pdf

Temporal Sequence of Visuo-Auditory Interaction in Multiple Areas of the Guinea Pig Visual Cortex Masataka Nishimura, Wen-Jie Song* Department of Sensory and Cognitive Physiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Abstract Recent studies in humans and monkeys have reported that acoustic stimulation influences visual responses in the primary visual cortex (V1). Such influences can be generated in V1, either by direct auditory projections or by feedback projections from extrastriate cortices. To test these hypotheses, cortical activities were recorded using optical imaging at a high spatiotemporal resolution from multiple areas of the guinea pig visual cortex, to visual and/or acoustic stimulations. Visuo- auditory interactions were evaluated according to differences between responses evoked by combined auditory and visual stimulation, and the sum of responses evoked by separate visual and auditory stimulations. Simultaneous presentation of visual and acoustic stimulations resulted in significant interactions in V1, which occurred earlier than in other visual areas. When acoustic stimulation preceded visual stimulation, significant visuo-auditory interactions were detected only in V1. These results suggest that V1 is a cortical origin of visuo-auditory interaction. Citation: Nishimura M, Song W-J (2012) Temporal Sequence of Visuo-Auditory Interaction in Multiple Areas of the Guinea Pig Visual Cortex. PLoS ONE 7(9): e46339. doi:10.1371/journal.pone.0046339 Editor: Jeff A. Beeler, University of Chicago, United States of America Received February 7, 2012; Accepted August 31, 2012; Published September 28, 2012 Copyright: 2012 Nishimura, Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction