Ⅱ型糖尿病患者血清岛素浓度与血糖、糖化血红蛋白、C肽及血压、血脂的相关性研究.doc

Ⅱ型糖尿病患者血清胰岛素浓度与血糖、糖化血红蛋白、C肽及血压、血脂的相关性研究 关心1，赵玉红1，平静2，王晓蕾1，李坚1，卢熠1，吴丽霞1. 1沈阳医学院沈洲医院, 沈阳110002；2 沈阳药科大学药学院, 沈阳110016 RELEVANCE STUDIES OF SERUM INSULIN CONCENTRATION, BLOOD GLUCOSE AND GLYCOSYLATED HEMOGLOBIN THE IN TYPE 2 DIABETES PATINTS Guan xin1, Zhao yuhong1, Ping jing2, Wang xiaolei 1, li jian1, Lu yi1 , Wu lixia1 1 Shenzhou Hospital affiliated Shenyang Medical College, Shenyang 110002; 2 Shenyang Pharmaceutical University, Shenyang 110016 [Abstract] Objective: To study fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), and insulin(Ins) concentrations 3 indicators of mutual relations in patients with type 2 diabetes and the clinical application. Method: FBG, HbAle, Ins concentrations were Respectively determined by enzymatic oxidation, immunization turbidity, chemiluminescence. After treatment of the diabetic patients 1 month and 2 months , we reexamined. Results: type 2 diabetes in the FBG, HbAlc, Ins were significantly higher than the normal control group (P 0.01). Conclusion: Glucose metabolism target and Ins level relations: in impaired glucose tolerance (IGT) to the clinical early time, has been in existence Ins resistance, the relative lack of Ins can compensatory increase in the FBG to maintain the normal limit level; Clinical early to mid-FBG increased, Ins resistance gradual increase, the Ins level relative insufficiency hastens obviously, β-cell function appears from strengthens to the weaken transformation, in blood Ins levels were unstable state of fluctuation, is in the earlier decompensated period; The clinical mid and late stage, appears continues high FBG, the serious Ins resistance still existed, starts to present the Ins to be absolutely insufficient, Beta cell function is in a decompensated period or the failure time, the blood insulin level reduces unceasingly. The entire diabetes course, the typical Ins concentration curve was inverted U-shaped approximately. As FBG, HBAIc, and Ins reflects the three different periods of FBG l