the crosstalk of ptgs2 and egf signaling pathways in colorectal cancerptgs2相声和表皮生长因子信号通路在结肠直肠癌.pdf

Cancers 2011, 3, 3894-3908; doi:10.3390/cancers3043894 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer Dingzhi Wang 1, Dianren Xia 1 and Raymond N. DuBois 1,2,* 1 Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; E-Mails: dwang11@ (D.W.); dxia@ (D.X.) 2 Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA * Author to whom correspondence should be addressed; E-Mail: rdubois@; Tel.: +1-713-745-4495; Fax: +1-713-792-6375. Received: 13 September 2011; in revised form: 7 October 2011 / Accepted: 9 October 2011 / Published: 14 October 2011 Abstract: Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer. Keywords: PTGS2; COX-2; EGFR; colorectal cancer 1. Introduction Colorect