yeast mitochondrial interactosome model metabolon membrane proteins complex involved in the channeling of adpatp该公司膜蛋白的酵母线粒体interactosome模型复杂的adpatp参与引导.pdf

Int. J. Mol. Sci. 2012, 13, 1858-1885; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Yeast Mitochondrial Interactosome Model: Metabolon Membrane Proteins Complex Involved in the Channeling of ADP/ATP Benjamin Clémençon INSERM U1055, Laboratory of Fundamental and Applied Bioenergetics, Joseph Fourier University, 2280 Rue de la piscine, BP 53 38041 Grenoble cedex 9, France; E-Mail: benjamin.clemencon@ibmm.unibe.ch; Tel.: +33-476-635-600; Fax: +33-476-514-930. Received: 11 November 2011; in revised form: 20 January 2012 / Accepted: 31 January 2012 / Published: 10 February 2012 Abstract: The existence of a mitochondrial interactosome (MI) has been currently well established in mammalian cells but the exact composition of this super-complex is not precisely known, and its organization seems to be different from that in yeast. One major difference is the absence of mitochondrial creatine kinase (MtCK) in yeast, unlike that described in the organization model of MI, especially in cardiac, skeletal muscle and brain cells. The aim of this review is to provide a detailed description of different partner proteins involved in the synergistic ADP/ATP transport across the mitochondrial membranes in the yeast Saccharomyces cerevisiae and to propose a new mitochondrial interactosome model. The ADP/ATP (Aacp) and inorganic phosph