Studies on the hepatocyte protective activity and the structure-activity.pdf

322 Original Paper Studies on the Hepatocyte Protective Activity and the Structure- Activity Relationships of Quinic Acid and Caffeic Acid Derivatives from the Flower Buds of Lonicera bournei 1, 2 2 2 2 1, Ting Xiang *, Quan-Bo Xiong , Adnyana I Ketut , Yasuhiro Tezuka , Takema Nagaoka , Li-Jun Wu *, Shigetoshi Kadota2 1 Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, People©s Republic of China 2 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan Received: June 8, 2000; Accepted: August 9, 2000 Abstract: 13 quinic acid derivatives along with caffeic acid, Materials and Methods methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract Reagents . of the flower buds of Lonicera bournei Hemsl., among which 8 l a i