array-comparative genomic hybridization reveals loss of socs6 is associated with poor prognosis in primary lung squamous cell carcinomaarray-comparative基因组杂交显示亏损socs6与预后不良相关原发性肺鳞状细胞癌.pdf

Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 Is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma 1,2 1,3 1,2 1 Krishna B. Sriram *, Jill E. Larsen , Santiyagu M. Savarimuthu Francis , Casey M. Wright , Belinda E. 4 4 5 6 1,2 1,2 Clarke , Edwina E. Duhig , Kevin M. Brown , Nicholas K. Hayward , Ian A. Yang , Rayleen V. Bowman , Kwun M. Fong1,2 1 School of Medicine, The University of Queensland, Brisbane, Queensland, Australia, 2 Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia, 3 Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Centre, Dallas, Texas, United States of America, 4 Department of Anatomical Pathology, The Prince Charles Hospital, Brisbane, Queensland, Australia, 5 Integrative Cancer Genomics Division, Translational Genomics Research Institute (TGen), Phoenix, Arizona, United States of America, 6 Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia Abstract Background: Primary tumor recurrence commonly occurs after surgical resection of lung squamous cell carcinoma (SCC). Little is known about the genes driving SCC recurrence. Methods: We used array comparative genomic hybridization (aCGH) to identify genes affected by copy number alterations that may be involved in SCC recurrence. Training and test sets of resected primary lung SCC were assembled. aCGH was used to determine genomic copy number in a training set of 62 primary lung SCCs