两亲性多糖的制备及其自聚集胶束的特性研究进展-食品科学.PDF

※专题论述 食品科学 2017, Vol.38, No.01 263 两亲性多糖的制备及其自聚集胶束的 特性研究进展 1 1 1,2,* 肖 丽 ，叶发银 ，赵国华 （1.西南大学食品科学学院，重庆 400715 ；2. 重庆市特色食品工程技术研究中心，重庆 400175 ） 摘  要：近年来，基于两亲性聚合物的胶束在生物学领域中的应用备受人们的关注，其中疏水改性多糖（两亲性多 糖）自聚集胶束是其中的典型例子。两亲性多糖在水相体系中可自发形成具有壳核结构的胶束，可用于疏水性物质 增溶、靶向运输、控制释放及提高其生物活性等。本文对两亲性多糖的制备方法、自聚集胶束的特性（临界胶束浓 ζ- pH 度、大小、形状、 电位、多分散指数、荷载能力等）及其影响因素（基质浓度、疏水化程度、分子质量、 值、 温度、添加物等）进行全面综述，同时对该领域今后的发展方向进行了展望。 关键词：两亲性多糖；胶束；制备；自聚集；特性；因素 Advances in Synthesis of Amphiphilic Polysaccharides and Properties of Their Self-aggregated Micelles 1 1 1,2,* XIAO Li , YE Fayin , ZHAO Guohua (1. College of Food Science, Southwest University, Chongqing 400715, China; 2. Chongqing Special Food Programme and Technology Research Center, Chongqing 400715, China) Abstract: In recent years, the application of amphiphilic polymer micelles especially hydrophobically-modified polysaccharides (amphiphilic polysaccharides) self-aggregated micelles in the field of biology has attracted increasing scientific interests. Amphiphilic polysaccharides can form a core-shell micellar structure in aqueous system, which can be used for solubilizing hydrophobic substances, targeted drug delivery, controlling release, improving biological activities and so on. This paper summarizes recent progress in the synthesis of amphiphilic