康莱特联合化疗治疗晚期大肠癌的疗效观察.doc

康莱特联合化疗治疗晚期大肠癌的疗效观察 论着 医学信息 MEDICALINFORMAT10NNo.022011?377? 康莱特联合化疗治疗晚期大肠癌的疗效观察 令晓玲赵达 兰州大学第一医院,甘肃兰州730000 【摘要】目的:观察康莱特注射液联合XELOX方案(氟尿嘧啶+草酸铂)的治疗晚期大肠癌的疗效,不良反应及对生活质量的影响.方法:将66例晚期 大肠癌患者随机分成两组.单纯化疗组(对照组)33例,采用XELOX方案:卡培他滨1000mg/m,第1—14天口服,奥沙利铂135mg/m,第1天.每3周一 次.康莱特联合化疗组(康莱特组)33例,化疗方案同对照组,于每周期化疗第一天开始静脉滴注康菜特注射液100ml/~,连用14天.两周期治疗结束后 对其近期疗效,毒副反应及生存质量进行评价.结果:康莱特组有效率为57.6%(19/33),对照组为36.3%(11/33).两组比较有显着性差异()(2=3.911,P :0.048).两组治疗后的生存质量改善有显着性差异(t=4.189,P=0.002).康莱特组的不良反应发生率低于对照组,且发生的程度较轻.结论:康莱特 联合化疗能提高有效率,降低不良反应,改善患者的生存质量. 【关键词】康莱特;卡培他滨+奥沙利铂;晚期大肠癌 d0i:10.3969/j.issn.1006—1959.2011.02.014文章编号:1006—1959(2011)一O2—0377—02 Shontermefficacyofcombinationofoxaliplatin,capecitabineandKanglaiteinthetreatmentofadvancedcolorectalcarcinomaLINGXiao—ling, ZHAODaTheFirstHospitalofLanzhonUniversity,l~zhou,730000China 【Abstract】Objective:Toobservetheclinicaleffcicacyandtoxicityofoxaliplatin,capecitabineandrecombinantKanglaiteinthetreatmentofadvancedcolorectal carcinoma.Methods:Randomlythirty—threepatientswithadvancedcolorectalcarcinomaweretreatedbyXELOXregimencombiningwithKanglaite,andthirty—three patientsweretreatedwithregimenalone.Kanglaitewasusedonthefirstdayofeachchemotherapycycleforconsecutive2weeks,andthedosagewBslOOml/d.XELOX ragimenincludedcapecitabine1000mg/mon1stand14thdaysandoxaliplatin135mg/monfirstday.Thetreatmentwasrepeatedeverythreeweeks.Theefficacy.side effectandqualityoflifewerecomparedaftertwocyclesofchemotherapy.Results:Responseratewas57.6%incombininggroupand33.3%ineontrelgroup.Therates weredifferentbetweenthetwogroups(x=3.911,P=0.048).Qualityoflifeincombininggroupwassignifieandyhigherthanthatineontmlgroupaftertreatment(t= 4189,P=0.002).Theincidenceofsideeffectsincombininggroupwaslowerthanthatincontrolgroup,andthedegreewasalsoslighter.Conclusion:Kanglaitein combinationwithXELOXregimencallbeusedforthetreatmentofadvancedeolorectalcarcinoma.Itcanimproveefficacyandthequalityoflife,andreducetheside effectofchemotherapy. 大肠癌是临床上最常见的恶性肿瘤之一,随着生活水平的提高和生活 方式的改变,大肠癌的发病率和死亡率呈逐年上升趋势.全