文档详情

zhu liqin-prediction and penetration of moxifloxacin human人类法沙星在中渗透.pdf

发布:2025-04-23约6.8万字共17页下载文档
文本预览下载声明

KoreanJPhysiolPharmacol

Vol19:99-104,March,2015pISSN1226-4512

eISSN2093-3827

PredictionofPharmacokineticsandPenetrationofMoxifloxacinin

HumanwithIntra-AbdominalInfectionBasedonExtrapolated

PBPKModel

1,2,1,2213

LiQinZhu*,JianWeiYang*,YuanZhang,YongMingWang,JianLeiZhang,YuanYuanZhao,and

2

WeiLinDong

1TianjinFirstCentralHospital,Tianjin300192,2TianjinMedicalUniversity,Tianjin300070,3The153CentralHospitalofthe

People’sLiberationArmy,Henan450000,

Theaimofthisstudyistodevelopaphysiologicallybasedpharmacokinetic(PBPK)modelinintra-

abdominalinfectedrats,andextrapolateittohumantopredictmoxifloxacinpharmacokineticsprofiles

invarioustissuesinintra-abdominalinfectedhuman.12maleratswithintra-abdominalinfections,

inducedbyEscherichiacoli,receivedasingledoseof40mg/kgbodyweightofmoxifloxacin.Blood

plasmawascollectedat5,10,20,30,60,120,240,480,1440minafterdruginjection.APBPKmodel

wasdevelopedinratsandextrapolatedtohumanusingGastroPlussoftware.Thepredictionswere

assessedbycomparingpredictionsandobservations.Intheplasmaconc

显示全部
相似文档