zhu liqin-prediction and penetration of moxifloxacin human人类法沙星在中渗透.pdf
KoreanJPhysiolPharmacol
Vol19:99-104,March,2015pISSN1226-4512
eISSN2093-3827
PredictionofPharmacokineticsandPenetrationofMoxifloxacinin
HumanwithIntra-AbdominalInfectionBasedonExtrapolated
PBPKModel
1,2,1,2213
LiQinZhu*,JianWeiYang*,YuanZhang,YongMingWang,JianLeiZhang,YuanYuanZhao,and
2
WeiLinDong
1TianjinFirstCentralHospital,Tianjin300192,2TianjinMedicalUniversity,Tianjin300070,3The153CentralHospitalofthe
People’sLiberationArmy,Henan450000,
Theaimofthisstudyistodevelopaphysiologicallybasedpharmacokinetic(PBPK)modelinintra-
abdominalinfectedrats,andextrapolateittohumantopredictmoxifloxacinpharmacokineticsprofiles
invarioustissuesinintra-abdominalinfectedhuman.12maleratswithintra-abdominalinfections,
inducedbyEscherichiacoli,receivedasingledoseof40mg/kgbodyweightofmoxifloxacin.Blood
plasmawascollectedat5,10,20,30,60,120,240,480,1440minafterdruginjection.APBPKmodel
wasdevelopedinratsandextrapolatedtohumanusingGastroPlussoftware.Thepredictionswere
assessedbycomparingpredictionsandobservations.Intheplasmaconc