the effect of diluted penetration enhancer in nebulized mist versus liquid drop preparation forms on retrobulbar blood flow in healthy human subjects稀释的影响渗透增强剂喷雾雾与液滴制备形式在健康人体眼球后的血液流动.pdf

Pharmaceutics 2012, 4, 377-384; doi:10.3390/pharmaceutics4030377 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article The Effect of Diluted Penetration Enhancer in Nebulized Mist versus Liquid Drop Preparation Forms on Retrobulbar Blood Flow in Healthy Human Subjects 1 2 1 1 1 Sally Primus , Ingrida Januleviciene , Brent Siesky , Austin Gerber , Patrick Egan , Annahita Amireskandari 1, Lina Siaudvytyte 2, Ruta Barsauskaite 2 and Alon Harris 1,* 1 Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA; E-Mails: sprimus@ (S.P.); bsiesky@ (B.S.); algerber@ (A.G.); eganp07@ (P.E.); aamiresk@ (A.A.) 2 Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, LT-50009 Kaunas, Lithuania; E-Mails: ingrida.januleviciene@kaunoklinikos.lt (I.J.); lynciuke@ (L.S.); rutabars@ (R.B.) * Author to whom correspondence should be addressed; E-Mail: alharris@; Tel.: +1-317-278-0177; Fax: +1-317-274-8992. Received: 10 April 2012; in revised form: 25 July 2012 / Accepted: 1 August 2012 / Published: 8 August 2012 Abstract: The aim of this study was to compare the effects of nebulized mist and liquid drop applications on retrobulbar blood flow. A prospective, non-randomized clinical trial was used to collect data from 40 healthy human eyes. Color Doppler Imaging determined peak systolic (PSV) and end diastolic (EDV) blood flow velocities and