CD7在儿童急性髓细胞性白血病中表达的临床意义.docx

CD7在儿童急性髓细胞性白血病中表达的临床意义

李争朱洁冯丹梁昌达

[关键词]?CD7；儿童；急性髓细胞性白血病；临床意义

[中图分类号]?R725.5；R733.7??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.12.006

The?clinical?significance?of?CD7?expression?in?children?acute?myeloid?leukemia

LI?Zheng1，?ZHU?Jie2，?FENG?Dan3，?LIANG?Changda1

1.Department?of?Hematology?and?Oncology，?Jiangxi?Province?Childrens?Hospital，?Nanchang?330006，?Jiangxi，?China;?2.Department?of?Nephrology，?Jiangxi?Province?Childrens?Hospital，?Nanchang?330006，?Jiangxi，?China;?3.Department?of?General?Surgery，?Jiangxi?Province?Childrens?Hospital，?Nanchang?330006，?Jiangxi，?China

[Abstract]?Objective?To?investigate?the?clinical?significance?of?CD7?expression?in?childhood?acute?myeloid?leukemia?（AML）.?Methods?A?retrospective?analysis?was?performed?on?60?children?with?AML?admitted?to?Jiangxi?Province?Childrens?Hospital?from?October?2016?to?December?2020.?According?to?the?results?of?immunophenotyping，?the?children?were?divided?into?CD7?positive?（CD7+）?group?and?CD7?negative?（CD7–）?group.?The?clinical?characteristics，?immunophenotype?and?treatment?effect?of?the?two?groups?were?compared.?Results?Among?60?children?with?AML，?18?cases?were?CD7+，?and?the?positive?rate?was?30.00%，?mainly?M2?and?M5，?the?expression?rate?of?M2?was?55.56%，?which?was?higher?than?that?of?other?subtypes.?The?CD7+?group?had?significantly?higher?white?blood?cell?count?and?bone?marrow?blast?granulocyte?count?than?the?CD7–?group?（P0.05）.?There?were?no?significant?differences?in?platelet?count，?hemoglobin，?lactate?dehydrogenase，?creatinine?and?other?laboratory?indicators?between?the?two?groups?（P0.05）.?After?1?course?of?standard?induction?chemotherapy，?the?CD7+?group?had?a?significantly?lower?complete?remission?rate?than?the?CD7–?group?（P0.05）.?There?was?no?statistically?significant?difference?（P0.05）?in?the?overall?survival??rate?and?disease?free?survival?rate?between?the?two?groups?of?patients?at?1?year?and?2?years.?Conclusion?Compared?with?CD7–?children，?the?peripheral?white?blood?cell?count?and?bo