PD-1及其配体在原发性干燥综合征患者唇腺中的表达及临床.PDF

临床与病理杂志 2017, 37(3) 456 J Clin Pathol Res doi: 10.3978/j.issn.2095-6959.2017.03.002 View this article at: /10.3978/j.issn.2095-6959.2017.03.002 PD-1及其配体在原发性干燥综合征患者唇腺中的表达及临床意义 杨月，侯佳奇，李国陵，薛鸾，张树辉 (上海中医药大学附属岳阳中西医结合医院风湿科，上海 200437) [摘　要] 目的：观察干燥综合征(Sjogren’s syndrome，SS)患者唇腺活检组织中程序性死亡分子-1(programmed death-1，PD-1)、程序性死亡配体-1(programmed death ligand-1，PD-L1)、程序性死亡配 体-2(programmed death ligand-2，PD-L2)的表达，以及其与临床病理特征的相关性。方法：对所有 患者和正常对照组的唇腺活检标本进行HE染色观察淋巴细胞浸润程度，免疫组织化学观察PD-1， PD-L1和PD-L2的表达。结果：SS患者唇腺活检组织中PD-1，PD-L1和PD-L2的表达较正常对照组 明显增强。SS患者唇腺活检标本淋巴细胞的浸润程度与PD-1和PD-L2的表达强度无明显相关性， 与PD-L1的表达强度呈正相关。SS患者疾病活动度评分与PD-1，PD-L1及PD-L2的表达强度均无明 显相关性。SS患者疾病损害评分与PD-1的表达强度无明显相关性，与PD-L1和PD-L2的表达强度呈 负相关。结论：PD-1，PD-L1及PD-L2在SS患者唇腺活检组织中的表达明显增强，PD-1/PD-L信号 通路可能在SS的免疫病理损害中起重要作用。 [关键词] 原发性干燥综合征；程序性死亡分子-1；程序性死亡配体 Expression and clinical significance of PD-1 and its ligands in salivary glands of patients with Sjogren’s syndrome YANG Yue, HOU Jiaqi, LI Guoling, XUE Luan, ZHANG Shuhui (Department of Rheumatology, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Chinese Medicine, Shanghai 200437, China) Abstract Objective: To investigate the expression and its relativity with the clinicopathological characteristics of programmed death-1 (PD-1) and its ligands PD-L1 and PD-L2 in salivary glands of patients with Sjogren’s syndrome (SS). Methods: We used HE staining to observe the lymphocyte infiltration while used immunohistochemistry to observe the expression of PD-1, PD-L1 a