Management of Congestive Heart Failure药理充血性心力衰竭ppt课件.ppt

Pharmacological Management of Congestive Heart Failure;EPIDEMIOLOGY OF CHF;PROGNOSIS ;射血分数（Ejection Fraction，EF);Subtypes of CHF;↑metabolic and oxygen demands;↓contractility (cardiomyopathy)↑afterload (elevated SVR, systemic vascular resistance);1.Thickened left ventricle (hypertrophic cardiomyopathy)2. stiff left ventricle (restrictive cardiomyopathy左心室硬化)3. ↑preload;CONSEQUENCES OF CHF; CHF makes the ventricular function cruve shift downward. ; TREATMENT OF CHF ;Effect of ACEIs;ACTION: ; INDICATIONS:  ;Effect of enalapril on the mortality of patients with CHF;Goal in this case is to reduce blood volume, not reduce blood pressure.; Effect of ?-blockers on the mortality of patients with CHF;VASODILATORS：;Inotropic agents used for CHF ;Squill(海葱）埃及人古罗马人，水肿，强心，健体Foxglove (1785)Strophanthus（毒毛旋花子，1890）; ; The mechanism of cardiac muscle contraction;The mechanism of CARDIAC GLYCOSIDES ;Mechanism;;Pharmacological Effects:;? ;INDICATIONS of DIGITALIS;PHARMACOKINETICS OF DIGITALIS ; IV Administration: ;DIGITALIZATION:  ;The half-life of the drug determines its duration of action:;;TOXICITY OF DIGITALIS: ;At-risk situations;ADVERSE EFFECTS OF DIGITALIS;地高辛【中毒救治】停药！！;Digoxin:Drug interaction amiodarone（胺碘酮）;Ventricular function curves in the normal heart ,HF, and in HF treated with digitalis;Action of β-adrenergic agonist on heart muscle;Treatment options for various stages of heart failure ;Use of multiple drugs in the treatment of HF;Thank you!