contribution of epithelial-mesenchymal transition to pancreatic cancer progression的贡献epithelial-mesenchymal过渡到胰腺癌的进展.pdf

Cancers 2010, 2, 2084-2097; doi:10.3390/cancers2042084 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression 1, 2 2 1,3,4 Seth B. Krantz *, Mario A. Shields , Surabhi Dangi-Garimella , David J. Bentrem and Hidayatullah G. Munshi 2,3,4,* 1 Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; E-Mail: dbentrem@ (D.J.B.) 2 Departments of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; E-Mail: marioshields2012@ (M.A.S.); s-dangi-garimella@ (S.D.) 3 Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA 4 Jesse Brown VA Medical Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60612, USA * Authors to whom correspondence should be addressed; E-Mails: h-munshi@ (H.G.M.); or s-krantz@ (S.B.K.); Tel.: +1-312-503-2301; Fax: +1-312-503-0386. Received: 24 October 2010; in revised form: 1 December 2010 / Accepted: 1 December 2010 / Published: 9 December 2010 Abstract: Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) c