targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach胰腺癌细胞靶向抗癌药物输送使用fucose-bound纳米颗粒的方法.pdf

Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach 1,2 1,2 1 1 1,2 Makoto Yoshida , Rishu Takimoto , Kazuyuki Murase , Yasushi Sato , Masahiro Hirakawa , 1,2 1,3 1 1 1 1 Fumito Tamura , Tsutomu Sato , Satoshi Iyama , Takahiro Osuga , Koji Miyanishi , Kohichi Takada , 1 3 1,2 Tsuyoshi Hayashi , Masayoshi Kobune , Junji Kato * 1 Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan, 2 Division of Clinical Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan, 3 Division of Molecular Oncology, Sapporo Medical University Graduate School of Medicine, chuo-ku, Sapporo, Japan Abstract Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. Numerous fucosylated antigens in sera serve as tumor markers for cancer detection and evaluation of treatment efficacy. Increased expression of fucosyltransferases has also been reported for pancreatic cancer. These enzymes accelerate malignant transformation through fucosylation of sialylated precursors, suggesting a crucial requirement for fucose by pancreatic cancer cells. With this in mind, we developed fucose-bound nanoparticles as vehicles for delivery of antica