small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness小动脉弹性降低系统性红斑狼疮患者没有增加媒体内膜厚度.pdf

Nienhuis et al. Arthritis Research Therapy 2010, 12:R181 /content/12/5/R181 RESEARCH ARTICLE Open Access Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness 1* 1 1 2 2 2 Hans LA Nienhuis , Karina de Leeuw , Johan Bijzet , Jasper J van Doormaal , Arie M van Roon , Andries J Smit , Reindert Graaff3 1 1 , Cees GM Kallenberg , Marc Bijl Abstract Introduction: The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation. Methods: Thirty SLE patients with inactive disease and 30 age- and sex-matched healthy controls were included. Twenty patients with essential hypertension (EH) served as positive control. SAE was assessed by pulse-wave analysis using tonometric recordings of the radial artery. IMT of the carotid arteries was measured by ultrasound. AGE accumulation was assessed with an AGE-reader. Endothelial activation markers and C-reactive protein (CRP) were determined by enzyme-linked immunosorbent assay (ELISA). Results: SAE was decreased in SLE (P = 0.01) and further decreased in EH (P 0.01) compared to healthy controls. IMT was increased in EH (P 0.05), but not in SLE. AGE accumulation was increased in SLE (P 0.05) and further increased in EH (P 0.01) compared to healthy controls. Endothelial activation markers and CRP were increased in SLE but not in EH. SAE related to AGE accumulation (r = -0.370, P 0.05), CRP (r = -0.429, P