sle – hematopoietic stem cell transplantation for systemic lupus erythematosus系统性红斑狼疮,系统性红斑狼疮的造血干细胞移植.pdf
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Commentary
SLE
Hematopoietic stem cell transplantation for systemic lupus
erythematosus
Richard K Burt and Ann E Traynor
Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois, USA
Correspondence: Richard K Burt (e-mail: rburt@)
Received: 5 Mar 2003 Accepted: 27 May 2003 Published: 26 Jun 2003
Arthritis Res Ther 2003, 5:207-209 (DOI 10.1186/ar786)
© 2003 BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362)
Abstract
Hematopoietic stem cell transplantation was first reported for patients with systemic lupus
erythematosus in 1997. The procedure has since been performed worldwide including in Europe, in
Brazil, and in China. A National Institutes of Health-funded phase III clinical trial of hematopoietic stem
cell transplantation for refractory systemic lupus erythematosus is anticipated to begin in 2003.
Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in
systemic lupus erythematosus.
Keywords: hematopoietic stem cell transplantation, lupus
Introduction 90 mg/kg equine antithymocyte globulin (ATG) (divided as
The prognosis of systemic lupus erythematosus (SLE) 30 mg/kg over 3 days) was selected.
markedly improved following the introduction of monthly
intravenous pulse cyclophosphamide (500–1000 mg/m2). To collect hematopoietic stem cells, they need to be mobi-
Nevertheless, despite pulse cyclophosphamide and lized into the peripheral blood with either a hematopoietic
advances in supporti
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