association of ncf2, ikzf1, irf8, ifih1, and tyk2 with systemic lupus erythematosusncf2协会ikzf1、irf8 ifih1,tyk2系统性红斑狼疮.pdf

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus 1,2 1,2 3 4 Deborah S. Cunninghame Graham , David L. Morris , Tushar R. Bhangale , Lindsey A. Criswell , Ann- ¨ 5 ¨ 6 7 7 1,2 Christine Syvanen , Lars Ronnblom , Timothy W. Behrens , Robert R. Graham , Timothy J. Vyse * 1 Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King’s College London, London, United Kingdom, 2 Academic Department of Rheumatology, Division of Immunology, Infection, and Inflammatory Diseases, School of Medicine, King’s College London, London, United Kingdom, 3 Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California, United States of America, 4 Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, University of California San Francisco, San Francisco, California, United States of America, 5 Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 6 Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 7 ITGR Human Genetics Group, Genentech, San Francisco, California, United States of America Abstract Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ,8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association