sleep modulates the neural substrates of both spatial and contextual memory consolidation睡眠调节的神经基质空间和上下文记忆的巩固.pdf

Sleep Modulates the Neural Substrates of Both Spatial and Contextual Memory Consolidation ´ 1,2 1,3 1 ` 1 1 Geraldine Rauchs , Pierre Orban , Christina Schmidt , Genevieve Albouy , Evelyne Balteau , 1 1 1 1 ´ 1 Christian Degueldre , Caroline Schnackers , Virginie Sterpenich , Gilberte Tinguely , Andre Luxen , Pierre Maquet1, Philippe Peigneux1,4* ` ` ´ ´ 1 Cyclotron Research Center, University of Liege, Liege, Belgium, 2 Inserm-EPHE-Universite de Caen Basse-Normandie, Unite de Recherche U923, GIP Cyceron, Caen, ´ ´ ´ France, 3 Functional Neuroimaging Unit, University of Montreal, Montreal, Canada, 4 UR2NF - Neuropsychology and Functional Neuroimaging Research Unit, Universite Libre de Bruxelles, Brussels, Belgium Abstract It is known that sleep reshapes the neural representations that subtend the memories acquired while navigating in a virtual environment. However, navigation is not process-pure, as manifold learning components contribute to performance, notably the spatial and contextual memory constituents. In this context, it remains unclear whether post-training sleep globally promotes consolidation of all of the memory components embedded in virtual navigation, or rather favors the development of specific repre