spatial relational memory requires hippocampal adult neurogenesis空间关系记忆需要成人海马神经发生.pdf

Spatial Relational Memory Requires Hippocampal Adult Neurogenesis 1,2. 1,2. 1,2 3 3 David Dupret , Jean-Michel Revest , Muriel Koehl , Franc¸ois Ichas , Francesca De Giorgi , Pierre Costet4, Djoher Nora Abrous1,2*, Pier Vincenzo Piazza1,2* ´ 1 INSERM U862, Institut F. Magendie, Bordeaux, France, 2 University of Bordeaux 2, Bordeaux, France, 3 INSERM E347, Institut Bergonie, University of Bordeaux 2, ´ ` Bordeaux, France, 4 Laboratoire de Transgenese, University of Bordeaux 2, Bordeaux, France Abstract The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning. Citation: Dupret D, Revest J-M, Koehl M, Ichas F, De Giorgi F, et al. (2008) Spatial Relational Memory Requires Hippocampal Adult Neurogenesis. PLoS ONE 3(4): e1959. doi:10.1371/journal.pone.0001959 Editor: