surprising complexity of the ancestral apoptosis network令人惊讶的祖先细胞凋亡网络的复杂性.pdf

Volume 8, Issue 10, Article R226Zmaseket al.2007 Open Access Research Surprising complexity of the ancestral apoptosis network ¤* ¤* † *‡ Christian M Zmasek , Qing Zhang , Yuzhen Ye and Adam Godzik Addresses: *Burnham Institute for Medical Research, North Torrey Pines Road, La Jolla, CA 92037, USA. †School of Informatics, Indiana University, E.10th Street, Bloomington, IN 47408, USA. ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, Gilman Drive, La Jolla, CA 92093, USA. ¤ These authors contributed equally to this work. Correspondence: Adam Godzik. Email: adam@ Published: 24 October 2007 Received: 20 July 2007 Revised: 24 October 2007 Genome Biology 2007, 8:R226 (doi:10.1186/gb-2007-8-10-r226) Accepted: 24 October 2007 The electronic version of this article is the complete one and can be found online at /2007/8/10/R226 © 2007 Zmasek et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. tebrates have multiple paralogs in cnidarian-bilaterian ancestEvolution of the apoptotic networkpA comparative genomics approach revealed that the genes for seors, suggesting a complex evolutionary history for this network.veral components of the apoptosis network with single copies i/p n ver- Abstract