context mediates antimicrobial efficacy of kinocidin congener peptide rp-1上下文介导kinocidin同类rp-1肽的抗菌功效.pdf

Context Mediates Antimicrobial Efficacy of Kinocidin Congener Peptide RP-1 Nannette Y. Yount1,2, Samuel E. Cohen1,2,3, Deborah Kupferwasser1,2, Alan J. Waring2,5,6,8, Piotr 5 7 2,4 5 1,2,5,8 Ruchala , Shantanu Sharma , Karlman Wasserman , Chun-Ling Jung , Michael R. Yeaman * 1 Division of Infectious Diseases, Los Angeles County-Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America, 2 Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California, United States of America, 3 School of Medicine, University of California Irvine, Irvine, California, United States of America, 4 Division of Pulmonary / Critical Care Medicine, Los Angeles County-Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America, 5 Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America, 6 Department of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, California, United States of America, 7 Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America, 8 Division of Molecular Medicine, Los Angeles County-Harbor University of California Los Angeles Medical Center, Torrance, California, United States of America Abstract Structure-mechanism relationships are key determinants of host defense peptide efficacy. These relationships are influenced by anatomic, physiologic and microbiologic contexts. Structure-mechanism correlates were assessed for the synthetic