biodegradable polydepsipeptides可生物降解polydepsipeptides.pdf

Int. J. Mol. Sci. 2009, 10, 589-615; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Biodegradable Polydepsipeptides Yakai Feng * and Jintang Guo * School of Chemical Engineering and Technology, Tianjin University / Weijin Road 92, 300072 Tianjin, P.R. China * Authors to whom correspondence should be addressed; E-Mail: yakaifeng@ (Y.F.); jtguo@ (J.G.); Tel. +86-22 Fax: +86-22 Received: 5 January 2009; in revised form: 10 February 2009 / Accepted: 13 February 2009 / Published: 13 February 2009 Abstract: This paper reviews the synthesis, characterization, biodegradation and usage of bioresorbable polymers based on polydepsipeptides. The ring-opening polymerization of morpholine-2,5-dione derivatives using organic Sn and enzyme lipase is discussed. The dependence of the macroscopic properties of the block copolymers on their structure is also presented. Bioresorbable polymers based on polydepsipeptides could be used as biomaterials in drug controlled release, tissue engineering scaffolding and shape-memory materials. Keywords: Polydepsipeptides; morpholine-2,5-dione; biomaterials; biodegradation; ring- opening polymerization. 1. Introduction Synthetic biodegradable polymeric materials are often used for biomedical applications such as surgical sutures, resorbable bone plates