the conservation and evolutionary modularity of metabolism保护和新陈代谢的进化模块化.pdf

Volume 10, Issue 6, Article R63et al.Peregrín-Alvarez2009 Open Access Research The conservation and evolutionary modularity of metabolism José M Peregrín-Alvarez*†, Chris Sanford*‡ and John Parkinson*‡§ Addresses: *Program in Molecular Structure and Function, Hospital for Sick Children, College Street, Toronto, ON, M5G 1L7, Canada. †Department of Molecular Biology and Biochemistry, University of Malaga, Avda. Cevantes, 29071 Malaga, Spain. ‡Department of Molecular Genetics, University of Toronto, Kings College Circle, Toronto, ON, M5S 1A8, Canada. §Department of Biochemistry, University of Toronto, Toronto, Kings College Circle, ON, M5S 1A8, Canada. Correspondence: José M Peregrín-Alvarez. Email: peregrin@sickkids.ca. John Parkinson. Email: jparkin@sickkids.ca Published: 12 June 2009 Received: 5 February 2009 Revised: 27 May 2009 Genome Biology 2009, 10:R63 (doi:10.1186/gb-2009-10-6-r63) Accepted: 12 June 2009 The electronic version of this article is the complete one and can be found online at /2009/10/6/R63 © 2009 Peregrín-Alvarez et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. pMetabolic modularitypA novel evolutionary analysis of metabolic networks across 26 taxa reveals a highly-conserved but flexible core of metabolic enzymes./ Abstract Background: Cellular metabolism is a fundamental biological system consisting of myriads of enzymatic reaction