conservation and occurrence of trans-encoded srnas in the rhizobiales保护和发生trans-encoded srna rhizobiales.pdf

Genes 2011, 2, 925-956; doi:10.3390/genes2040925 OPEN ACCESS genes ISSN 2073-4425 /journal/genes Article Conservation and Occurrence of Trans-Encoded sRNAs in the Rhizobiales ¨ Jan Reinkensmeier , Jan-Philip Schluter , Robert Giegerich and Anke Becker ¨ Center for Biotechnology (CeBiTec), Bielefeld University, Universitatsstraße 27, 33615 Bielefeld, Germany; E-Mails: jreinken@cebitec.uni-bielefeld.de (J.R.); robert@techfak.uni-bielefeld.de (R.G.) ¨ Institute of Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, Schanzlestraße 1, 79102 Freiburg, Germany; E-Mail: jan-philip.schlueter@biologie.uni-freiburg.de These authors contributed equally to this work. Author to whom correspondence should be addressed; E-Mail: anke.becker@uni-freiburg.de; Tel.: +49-761-203-6948. Received: 31 August 2011; in revised form: 24 October 2011 / Accepted: 26 October 2011 / Published: 18 November 2011 Abstract: Post-transcriptional regulation by trans-encoded sRNAs, for example via base-pairing with target mRNAs, is a common feature in bacteria and influences various cell processes, e.g., response to stress factors. Several studies based on computational and RNA-seq approaches identified approximately 180 trans-encoded sRNAs in Sinorhizobium meliloti. The initial point of this report is a