arthropod borne disease the leading cause of fever in pregnancy on the thai-burmese border节肢动物传播疾病在怀孕发烧的主要原因在泰缅边境.pdf

Arthropod Borne Disease: The Leading Cause of Fever in Pregnancy on the Thai-Burmese Border 1,2,3 1,4 2,3 1 Rose McGready *, Elizabeth A. Ashley , Vanaporn Wuthiekanun , Saw Oo Tan , Mupawjay 1 1 2 2,3 Pimanpanarak , Samuel Jacher Viladpai-nguen , Wilarat Jesadapanpong , Stuart D. Blacksell , 2,5 2,3 2,3 2 2,3 Sharon J. Peacock , Daniel H. Paris , Nicholas P. Day , Pratap Singhasivanon , Nicholas J. White , Franc¸ois Nosten1,2,3 1 Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand, 2 Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand, 3 Centre for Tropical Medicine, Churchill Hospital, Oxford, United Kingdom, 4 Imperial College NHS Trust, London, United Kingdom, 5 Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom Abstract Background: Fever in pregnancy is dangerous for both mother and foetus. In the 1980’s malaria was the leading cause of death in pregnant women in refugee camps on the Thai-Burmese border. Artemisinin combination therapy has significantly reduced the incidence of malaria in the population. The remaining causes of fever in pregnancy are not well documented. Methodology: Pregnant women attending antenatal care, where weekly screening for malaria is routine, were invited to have a comprehensive clinical and laboratory screen