biocompatible polymerquantum dots hybrid materials current status and future developments生物相容性polymerquantum点混合材料的现状和未来的发展.pdf

J. Funct. Biomater. 2011, 2, 355-372; doi:10.3390/jfb2040355 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb/ Review Biocompatible Polymer/Quantum Dots Hybrid Materials: Current Status and Future Developments Lei Shen Department of Chemistry Biochemistry, The University of Texas at Austin, TX 78712, USA; E-Mail: shenl@; Tel.: +1-512-471-2589 Received: 6 October 2011; in revised form: 23 November 2011 / Accepted: 28 November 2011 / Published: 2 December 2011 Abstract: Quantum dots (QDs) are nanometer-sized semiconductor particles with tunable fluorescent optical property that can be adjusted by their chemical composition, size, or shape. In the past 10 years, they have been demonstrated as a powerful fluorescence tool for biological and biomedical applications, such as diagnostics, biosensing and biolabeling. QDs with high fluorescence quantum yield and optical stability are usually synthesized in organic solvents. In aqueous solution, however, their metallic toxicity, non-dissolubility and photo-luminescence instability prevent the direct utility of QDs in biological media. Polymers are widely used to cover and coat QDs for fabricating biocompatible QDs. Such hybrid materials can provide solubility and robust colloidal and optical stability in water. At