single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer单细胞测序分析特征共同muscle-invasive膀胱癌和cell-lineage-specific突变.pdf

Li et al. GigaScience 2012, 1:12 /content/1/1/12 RESEARCH Open Access Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer 1† 1† 1,2,3,4† 1,5,6† 7,8,9† 10 1 Yingrui Li , Xun Xu , Luting Song , Yong Hou , Zesong Li , Shirley Tsang , Fuqiang Li , 11 1 1,12 1 1 1 1 1 1,5,6 Kate McGee Im , Kui Wu , Hanjie Wu , Xiaofei Ye , Guibo Li , Linlin Wang , Bo Zhang , Jie Liang , Wei Xie , Renhua Wu1 1 1 1 1 1 13 14 13 , Hui Jiang , Xiao Liu , Chang Yu , Hancheng Zheng , Min Jian , Liping Nie , Lei Wan , Min Shi , 7,8,9 7,8,9 1 13 8,9,13 1 2 Xiaojuan Sun , Aifa Tang , Guangwu Guo , Yaoting Gui , Zhiming Cai , Jingxiang Li , Wen Wang , Zuhong Lu5,6 1 1,15 1,16 1 1* , Xiuqing Zhang , Lars Bolund , Karsten Kristiansen , Jian Wang , Huanming Yang , Michael Dean11* and Jun Wang1,16,17* Abstract Background: Cancers arise through an evolutionary process in which cell populations are subjected to selection; however, to date, the process of bladder cancer, which is one of the most common cancers in the world, remains unknown at a single-cell level. Results: We carried out si