temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury时间基于网络分析的细胞特定静脉移植物转录组定义了关键路径和中心基因植入损伤.pdf

Temporal Network Based Analysis of Cell Specific Vein Graft Transcriptome Defines Key Pathways and Hub Genes in Implantation Injury 2 1 1 1 2 Manoj Bhasin , Zhen Huang , Leena Pradhan-Nabzdyk , Junaid Y. Malek , Philip J. LoGerfo , 1 1 4 1 3 Mauricio Contreras , Patrick Guthrie , Eva Csizmadia , Nicholas Andersen , Olivier Kocher , 1,5 1 Christiane Ferran *, Frank W. LoGerfo * 1 Division of Vascular and Endovascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Genomics and Proteomics Center, Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Deptartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Center for Vascular Biology Research and Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft implantation injury was determined by transcriptional profiling of laser capture microdissected