consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation a meta-analysis冷缺血时间在原发性无功能的后果,病人和移植肝的生存在肝移植一个荟萃分析.pdf

Consequences of Cold-Ischemia Time on Primary Nonfunction and Patient and Graft Survival in Liver Transplantation: A Meta-Analysis 1,2,3 4 6 4,5 7 James E. Stahl *, Jennifer E. Kreke , Fawaz Ali Abdul Malek , Andrew J. Schaefer , Joseph Vacanti 1 MGH- Institute for Technology Assessment, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 5 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 6 Industrial and Management Systems Engineering Department, University of Kuwait, Kuwait City, Kuwait, 7 Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Introduction: The ability to preserve organs prior to transplant is essential to the organ allocation process. Objective: The purpose of this study is to describe the functional relationship between cold-ischemia time (CIT) and primary nonfunction (PNF), patient and graft survival in liver transplant. Methods: To identify relevant articles Medline, EMBASE and the Cochrane database, including the non-English literature identified in these databases, was searched from 1966 to April 2008. Two independent reviewers screened and extracted the data. CIT was analyzed both as a continuous variable an