striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance纹状体体积的增加活跃methamphetamine-dependent个人和相关认知能力.pdf

Brain Sci. 2012, 2, 553-572; doi:10.3390/brainsci2040553 OPEN ACCESS brain sciences ISSN 2076-3425 /journal/brainsci/ Article Striatal Volume Increases in Active Methamphetamine-Dependent Individuals and Correlation with Cognitive Performance Reem K. Jan 1,2,*, Joanne C. Lin 1,2, Sylvester W. Miles 3,4, Rob R. Kydd 2,4 and Bruce R. Russell 1,2 1 School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; E-Mails: joanne.lin@auckland.ac.nz (J.C.L.); b.russell@auckland.ac.nz (B.R.R.) 2 Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; E-Mail: r.kydd@auckland.ac.nz 3 Waitemata District Health Board, Private Bag 93503, Takapuna, Auckland 0740, New Zealand; E-Mail: es@t.nz 4 Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand * Author to whom correspondence should be addressed; E-Mail: r.jan@auckland.ac.nz; Tel.: +64-9-923-6429; Fax: +64-9-367-7192. Received: 31 July 2012; in revised form: 10 September 2012 / Accepted: 24 October 2012 / Published: 30 October 2012 Abstract: The effect of methamphetamine (MA) dependence on the structure of the human brain has not been extensively studied, especially in active users. Previous studies reported cortical deficits and striatal gains in grey matter (GM) volume of abstinent MA abusers compared with control participants. This study aim