GDF11 Increases with Age and Inhibits Skeletal （GDF11随着年龄的增加,抑制骨骼）.pdf

Article GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration Graphical Abstract Authors Marc A. Egerman, Samuel M. Cadena, Jason A. Gilbert, ..., Anne-Ulrike Trendelenburg, Andrew S. Brack, David J. Glass Correspondence david.glass@ In Brief Previous studies showed that GDF11 decreases with age and that GDF11 treatment improves muscle regeneration. Egerman et al. carefully re-assess this hypothesis and discover that the previously used reagents to detect GDF11 are nonspecific and that GDF11 actually increases with age and has deleterious effects on aging skeletal muscle. Highlights