association of the european lactase persistence variant (lct-13910 ct polymorphism) with obesity in the canary islands协会欧洲乳糖耐受性的变异与肥胖(lct - 13910 ct多态性)在加那利群岛.pdf

Association of the European Lactase Persistence Variant (LCT-13910 C.T Polymorphism) with Obesity in the Canary Islands 1 ´ ´ 2 ´ 2 Ricardo Almon *, Eva Elisa Alvarez-Leon , Lluıs Serra-Majem ¨ ¨ 1 Family Medicine Research Centre, School of Health and Medical Sciences, Orebro University, Orebro, Sweden, 2 Preventive Medicine Service, Canary Health Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Canary Islands, Spain Abstract Background: European lactose tolerance genotype (LCT -13910 C.T, rs4988234) has been positively associated to body mass indexes (BMI) in a meta-analysis of 31,720 individuals of northern and central European descent. A strong association of lactase persistence (LP) with BMI and obesity has also been traced in a Spanish Mediterranean population. The aim of this study was to analyze a potential association of LP compared to lactase non-persistence (LNP) with BMI in inhabitants of the Canary Islands of Spain using Mendelian randomization. Methods: A representative, randomly sampled population of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain, aged 18–75 years (n = 551), was genotyped for the LCT – 13910 C.T polymorphism. Milk consumption was assessed by a validated questionnaire. Anthropometric variables were directly measured. WHO classification of BMI was used. Results: LP individuals were significantly more obese than LNP subjects (x2 = 10.59; p ,0.005). LP showed in a multivariate linear regression analysis showed a positive association of LP with BMI compared to LNP, (b = 0.96; 95% CI: 0.08–1.85, p = 0.033). In a multinomial logi