the dynamics of developmental and tumor angiogenesis—a comparison的动态发展和肿瘤angiogenesis-a比较.pdf

Cancers 2012, 4, 400-419; doi:10.3390/cancers4020400 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review The Dynamics of Developmental and Tumor Angiogenesis—A Comparison Yi Jin and Lars Jakobsson * Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE-17177, Sweden; E-Mail: Yi.jin@ki.se * Author to whom correspondence should be addressed; E-Mail: Lars.jakobsson@ki.se; Tel.: +46-0-8-5248-7923; Fax: +46-0-8-313-445. Received: 1 March 2012; in revised form: 3 April 2012 / Accepted: 4 April 2012 / Published: 11 April 2012 Abstract: The blood vasculature in cancers has been the subject of intense interest during the past four decades. Since the original ideas of targeting angiogenesis to treat cancer were proposed in the 1970s, it has become evident that more knowledge about the role of vessels in tumor biology is needed to fully take advantage of such strategies. The vasculature serves the surrounding tissue in a multitude of ways that all must be taken into consideration in therapeutic manipulation. Aspects of delivery of conventional cytostatic drugs, induction of hypoxia affecting treatment by radiotherapy, changes in tumor cell metabolism, vascular leak and trafficking of leukocytes are affected by interventions on vascular function. Many tumors constitute a highly interchangeable milieu undergoing proliferation, apoptosis, and necrosis with abundance of g