stress alters the discriminative stimulus and response rate effects of cocaine differentially in lewis and fischer inbred rats压力改变了歧视的可卡因刺激和反应率的影响差异在路易斯和费舍尔天生的老鼠.pdf

Behav. Sci. 2012, 2, 23-37; doi:10.3390/bs2010023 OPEN ACCESS Behavioral Sciences ISSN 2076-328X /journal/behavsci/ Article Stress Alters the Discriminative Stimulus and Response Rate Effects of Cocaine Differentially in Lewis and Fischer Inbred Rats Therese A. Kosten 1, * and Mindy J. D. Miserendino 2 1 Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine and the Michael E Debakey Veteran’s Administration Medical Center, 2002 Holcombe Blvd., Houston, TX 77030, USA 2 Department of Psychology, Sacred Heart University, 5151 Park Ave, Fairfield, CT 06825, USA; E-Mail: MiserendinoM@ * Author to whom correspondence should be addressed; E-Mail: tkosten@; Tel.: +1-713-794-7637; Fax: +1-713-794-7240. Received: 19 January 2012; in revised form: 9 February 2012 / Accepted: 17 February 2012 / Published: 1 March 2012 Abstract: Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self-administration. We hypothesized that stress would differentially affect cocaine behaviors in these strains. The effects of three stressors on the discriminative stimulus and response rate effects of cocaine were investigated. Rats of both strains were trained to discriminate cocaine