孟鲁司特对哮喘患儿外周血Th1Th2细胞功能平衡调节作用机制研究.doc

孟鲁司特对哮喘患儿外周血Th1Th2细胞功能平衡调节作用机制研究 　　[摘要] 目的：探讨孟鲁司特的临床疗效及其对哮喘患儿外周血Th1/Th2细胞功能平衡的调节作用机制。方法：将2008年12月~2010年12月我院收治的支气管哮喘患儿78例随机分为治疗组和对照组，每组各39例。两组均给予吸氧、平喘、抗炎、抗感染等基础治疗，其中，治疗组在上述治疗的基础上给予孟鲁司特片4 mg/d，口服，1次/d，连用3个月。观察比较两组治疗前和治疗3个月后IL-4、IFN-γ含量及IFN-γ/IL-4比值的变化，对两组的总有效率进行比较，并观察两组咳嗽、喘息及哮鸣音消失时间。结果：治疗组IFN-γ[（76.16±7.42）ng/L]较对照组[（74.53±7.56）ng/L]明显升高（t=2.42，P＜0.05）；治疗组IL-4[（41.45±6.61）ng/L]较对照组[（46.57±7.42）ng/L]明显降低（t=2.68，P＜0.05）；治疗组IFN-γ/IL-4值（1.83±0.42）较对照组（1.56±0.37）明显上升（t=2.13，P＜0.05）；治疗组的总有效率为92.31%，与对照组相比（74.36%），差异有高度统计学意义（χ2=12.537，P＜0.01）；治疗组的咳嗽、喘息、哮鸣音消失时间[（2.68±1.15）、（5.19±1.25）、（4.17±1.75）d]均明显短于对照组[（4.43±1.27）、（6.70±1.63）、(6.25±1.64）d]，差异有高度统计学意义（t=2.35、2.14、2.41，P＜0.01）。结论：孟鲁司特治疗小儿支气管哮喘疗效好，可以明显改善患儿的临床症状与体征，且安全性好，可能与其对支气管哮喘患儿Th1/Th2细胞功能平衡紊乱的调节作用有关。 　　[关键词] 孟鲁司特；支气管哮喘；Th1/Th2细胞；调节作用 　　[中图分类号] R725.6 [文献标识码] A [文章编号] 1673-7210（2011）11（b）-064-03 　　 　　Analysis of the balance regulation mechanism of Montelukast on Th1/Th2 cell function of peripheral blood in asthmatic children 　　WANG Xiuhua, LI Jing, GUO Hong, CAO Weifang 　　Department of Pediatrics, Daqing Oil General Hospital, Heilongjiang Province, Daqing 163001, China 　　[Abstract] Objective: To investigate the clinical efficacy of Montelukast and to explore its balance regulation mechanism of Montelukast on Th1/Th2 cell function of peripheral blood in asthmatic children. Methods: 78 cases of children with bronchial asthma were randomly divided into treatment group and control group in our hospital from December 2008 to December 2010, 39 cases in each group. Oxygen uptake, relieving asthma, anti-inflammatory, anti-infection and other basic treatment were given to both groups, thus Montelukast tablets 4 mg/d, orally, once a day for three months were given to the treatment group on the basis of basic treatment. IL-4, IFN-γ levels and IFN-γ/IL-4 ratio changes before and after 3 months treatment were compared, the total efficiency of the two groups were compared, and the disappearance time of cough, asthma and whee