comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats蜂蜜的抗氧化效果,比较格列本脲、二甲双胍,其体外糖尿病大鼠肾脏的组合.pdf

Int. J. Mol. Sci. 2011, 12, 829-843; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Comparison of Antioxidant Effects of Honey, Glibenclamide, Metformin, and Their Combinations in the Kidneys of Streptozotocin-Induced Diabetic Rats Omotayo Owomofoyon Erejuwa 1,*, Siti Amrah Sulaiman 1, Mohd Suhaimi Ab Wahab 1, 2 3 4 Sirajudeen Kuttulebbai Nainamohammed Salam , Md Salzihan Md Salleh and Sunil Gurtu 1 Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; E-Mails: sbsamrah@kb.usm.my (S.A.S.); msuhaimi@kb.usm.my (M.S.A.W.) 2 Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; E-Mail: sirajuden@kb.usm.my 3 Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; E-Mail: matledpb@ 4 School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor, Malaysia; E-Mail: sgurtu@ * Author to whom correspondence should be addressed; E-Mail: erejuwa@; Tel.: +609-7666-877; Fax: +609-7653-370. Received: 29 October 2010; in revisedform: 7 December 2010 / Accepted: 21 December 2010 / Published: 21 January 2011 Abstract: Hyperglycemia-induced