synthesis and evaluation of non-peptidic cysteine protease inhibitors of p. falciparum derived from etacrynic acid合成和评价non-peptidic半胱氨酸蛋白酶抑制剂的恶性疟原虫源自etacrynic酸.pdf

Molecules 2009, 14, 19-35; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid 1 2 2 2 Marie-Adrienne Dude , Ulrich Kaeppler , Monika Herb , Markus Schiller , Franziska 3 2 3 1 4 4 Schulz , Birgit Vedder , Saskia Heppner , Gabriele Pradel , Jiri Gut , Philip J. Rosenthal , Tanja Schirmeister 2, Matthias Leippe 3 and Christoph Gelhaus 3,* 1 Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany; E-mail: adrienne.dude@uni-wuerzburg.de (M-A. D.), gabriele.pradel@mail.uni-wuerzburg.de (G. P.) 2 Institute of Pharmacy and Food Chemistry, Am Hubland, D-97074 Würzburg, Germany E-mail: schirmei@pharmazie.uni-wuerzburg.de (T. S.) 3 Zoological Institute, University of Kiel, Olshausenstr. 40, D-24098 Kiel, Germany E-mail: mleippe@zoologie.uni-kiel.de (M. L.) 4 Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143-0811, USA; E-mail: philip.rosenthal@ (P-J. R.) * Author to whom correspondence should be addressed; E-mail: cgelhaus@zoologie.uni-kiel.de. Received: 20 November 2008; in revised form: 12 December 2008 / Accepted: 19 December 2008 / Published: 23 December 2008 Abstract: A series