biochemical properties of a novel cysteine protease of plasmodium vivax, vivapain-4生化特性间日疟原虫的一种新颖的半胱氨酸蛋白酶,vivapain-4.pdf

Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4 1,2. 1. 1 3 1 Byoung-Kuk Na , Young-An Bae , Young-Gun Zo , Youngchool Choe , Seon-Hee Kim , Prashant 4 5 3 6 7 1 V. Desai , Mitchell A. Avery , Charles S. Craik , Tong-Soo Kim , Philip J. Rosenthal , Yoon Kong * 1 Department of Molecular Parasitology and Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, 2 Department of Parasitology and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea, 3 Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, 4 Department of Medicinal Chemistry, National Center for Natural Products Research, University of Mississippi, University, Mississippi, United States of America, 5 Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi, Unites States of America, 6 Department of Parasitology, Inha University College of Medicine, Incheon, Korea, 7 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America Abstract Background: Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic proteases (plasmepsins) in the acidic fo