α-galactosylceramide analogs with weak agonist activity for human inkt cells define new candidate anti-inflammatory agentsα-galactosylceramide类似物受体激动剂对人类活动较弱inkt细胞抗炎剂定义新的候选人.pdf

a-Galactosylceramide Analogs with Weak Agonist Activity for Human iNKT Cells Define New Candidate Anti-Inflammatory Agents 1 1 1 1 3 Gabriel Bricard , Manjunatha M. Venkataswamy , Karl O. A. Yu , Jin S. Im , Rachel M. Ndonye , 3 4 4 4 5¤ 5 Amy R. Howell , Natacha Veerapen , Petr A. Illarionov , Gurdyal S. Besra , Qian Li , Young-Tae Chang , Steven A. Porcelli1,2* 1 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, 3 Department of Chemistry, University of Connecticut, Storrs, Connecticut, United States of America, 4 School of Biosciences, University of Birmingham, Edgbaston, United Kingdom, 5 Department of Chemistry, National University of Singapore, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore Abstract CD1d-restricted natural killer T cells with invariant T cell receptor a chains (iNKT cells) are a unique lymphocyte subset that responds to recognition of specific lipid and glycolipid antigens. They are conserved between mice and humans and exert various immunoregulatory functions through their rapid secretion of a variety of cytokines and secondary activation of dendritic cells, B cells and NK cells. In the current study, we analyzed the range of functional activation states of human iNKT cells using a library of novel analogs of a-galactosylceramide (aGalCer), the prototypical iNKT cell a