systematic evaluation of candidate blood markers for detecting ovarian cancer系统评价候选人的血液标记检测卵巢癌.pdf

Systematic Evaluation of Candidate Blood Markers for Detecting Ovarian Cancer 1 2 1 3 4 2 Chana Palmer , Xiaobo Duan , Sarah Hawley , Nathalie Scholler , Jason D. Thorpe , Rob A. Sahota , 2 2 4 4 4 May Q. Wong , Andrew Wray , Lindsay A. Bergan , Charles W. Drescher , Martin W. McIntosh , Patrick O. 5 2 4 Brown , Brad H. Nelson , Nicole Urban * 1 Canary Foundation, Scientific Programs, San Jose, California, United States of America, 2 British Columbia Cancer Agency, Trev Joyce Deeley Research Center, Victoria, Canada, 3 Department of Gynecology and Obstetrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 4 Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, United States of America, 5 Department of Biochemistry, Stanford University, Stanford, California, United States of America, 6 Howard Hughes Medical Institute, Stanford, California, United States of America Abstract Background: Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor. Early detection of epithelial ovarian cancer, and of the serous subtype in particular, is a promising strategy for saving lives. The low prevalence of ovarian cancer makes the development of an adequately sensitive and specific test based on blood markers very challenging. We evaluated the performance of a set