the calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat降钙素受体基因是一个候选人的监管对单纯疱疹1型神经感染导致老鼠脑炎.pdf

The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat 1 1,2 ´ 1 1 Nada Abdelmagid *, Biborka Bereczky-Veress , Andre Ortlieb Guerreiro-Cacais , Petra Bergman , 3 ¨ 4 ¨ 2 1 1. Katarina M. Luhr , Tomas Bergstrom , Birgit Skoldenberg , Fredrik Piehl , Tomas Olsson , Margarita Diez1. 1 Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2 Department of Medicine, Infectious Disease Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 3 Department of Neuroscience, Neurodegenerative Diseases Unit, ¨ ¨ Karolinska Institutet, Stockholm, Sweden, 4 Department of Clinical Virology, Goteborgs Universitet, Goteborg, Sweden Abstract Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3–31 Mb; LOD score 2