deciphering the molecular nature of ovarian cancer biomarker ca125破译卵巢癌生物标志物ca125的分子性质.pdf

Int. J. Mol. Sci. 2012, 13, 10568-10582; doi:10.3390/ijms130810568 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125 Florian Weiland 1,†, Karina Martin 1,†, Martin K. Oehler 2 and Peter Hoffmann 1,* 1 Adelaide Proteomics Centre, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia; E-Mails: florian.weiland@.au (F.W.); karina.martin@.au (K.M.) 2 Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, SA 5005, Australia; E-Mail: martin.oehler@.au † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: peter.hoffmann@.au; Tel.: +61-8-8313-5507; Fax: +61-8-8313-4362. Received: 2 July 2012; in revised form: 3 July 2012 / Accepted: 13 August 2012 / Published: 22 August 2012 Abstract: The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning