基因芯片Application of DNA chip techniques for Yq microdeletion analysis in infertile males.pdf
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EXPERIMENTAL and MOLECULAR MEDICINE, Vol. 36, No. 2, 179-184, April 2004
Application of DNA chip techniques for Yq m icrodeletion
analysis in infertile m ales
S u m a n L e e 1*, H y u n S u k J o o 2 * The application of DNA chip technology to identify
S o o k -H w a n L e e 1 , J u n g E u n P a rk 2 Yq deletions can also facilitate our understanding
J o n g M a n K im 2 , J a e H o o n H w a n g 2 of m ale infertility.
K ey S eu n g C h o 2 an d S eu n g Y o n g H w an g 2,3 Keywords: DNA chip; male infertility; microdeletion;
1 molecular diagnosis; STS
Genome Research Center for
Reproductive Medicine and Infertility
Infertility Medical Center, CHA General Hospital
College of Medicine, Pochon CHA University Introduction
Seoul 135-913, Korea
2 Department of Biochemistry MicroBiochip Center Y-chromosomal deletions represent the most frequent
Hanyang University GenoCheck Co. Ltd. genetic alterations in infertile men (Chandley and
Ansan, Gyeonggi-do 426-791, Korea Cooke, 1994). The frequency of deletions on the long
3Corresponding author: Tel, 82-31-400-5516; arm of the Y chromosome (Yq) in infertile male
Fax, 82-31-502-5518; E-mail, syhwang@hanyang.ac.kr patients varies from 1% to 51% depending on patient
*These authors contributed equally to this work. se
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