synthesis and chemical characterisation of new bis-thieno [2,3-b]thiophene derivatives合成和化学描述新bis-thieno[2,3 b]噻吩衍生物.pdf

,Molecules 2010, 15, 3329-3337; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Chemical Characterisation of New Bis-Thieno [2,3-b]thiophene Derivatives Yahia Nasser Mabkhoot Department of Chemistry, Science of College, King Saud University, PO Box 2455, Riyadh-11451, Saudi Arabia; E-Mail: yahia@.sa Received: 5 March 2010; in revised form: 29 April 2010 / Accepted: 6 May 2010 / Published: 7 May 2010 Abstract: Using 3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-dicarbohydrazide as synthon a series of new bis-heterocycles incorporating the thieno[2,3-b]thiophene nucleus was prepared and characterized. Keywords: thieno[2,3-b]thiophene; 2,5-dicarbohydrazide; 5-Amino-3-cyano(1,2,3)tria- zole-1-carbonyl 1. Introduction Thienothiophene derivatives represent important building blocks in organic and medicinal chemistry. They have been developed for different pharmaceutical purposes and have been tested as potential antitumor, antiviral, antibiotic, and antiglaucoma drugs, or as inhibitors of platelet aggregation [1–6]. On the other hand, hydrazone derivatives are reported to possess antimicrobial [7], antitubercular [8], anticonvulsant [9] and anti-inflammatory [10] activities. The utility of hydrazides as key intermediates in the synthesis of several series of heterocyclic compounds and the broad spectrum of biological activities that have been reported for their cyclized products [11– 1