association of body mass and brain activation during gastric distention implications for obesity体重和大脑活动协会在胃膨胀对肥胖的影响.pdf

Association of Body Mass and Brain Activation during Gastric Distention: Implications for Obesity 1 2,3 2 4 5 1 Dardo Tomasi *, Gene-Jack Wang , Ruiliang Wang , Walter Backus , Allan Geliebter , Frank Telang , 1 1 2,3 1,6 Millar C. Jayne , Christopher Wong , Joanna S. Fowler , Nora D. Volkow 1 National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Medical Department, Brookhaven National Laboratory, Upton, New York, United States of America, 3 Department of Psychiatry, Mt Sinai School of Medicine, New York, New York, United States of America, 4 Depertment of Anesthesiology, SUNY, Stony Brook, New York, United States of America, 5 St. Luke’s/Roosevelt Hospital, Columbia University, New York, New York, United States of America, 6 National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, United States of America Abstract Background: Gastric distention (GD), as it occurs during meal ingestion, signals a full stomach and it is one of the key mechanisms controlling food intake. Previous studies on GD showed lower activation of the amygdala for subjects with higher body mass index (BMI). Since obese subjects have dopaminergic deficits that correlate negatively with BMI and the amygdala is innervated by dopamine neurons, we hypothesized that BMI would correlate negatively with activation not just in the amygdala but also in other dopaminergic brain regions (midbrain and hypothalamus). Methodology/Principal Findings: We used functional magnetic resonance imaging (f