work-related exhaustion and telomere length a population-based study工作疲劳和端粒长度以人群为基础的研究.pdf

Work-Related Exhaustion and Telomere Length: A Population-Based Study 1 ´ 2,3 ¨ 1,4,5 6,7,8 9 ¨ 10,11 Kirsi Ahola *, Ilari Siren , Mika Kivimaki , Samuli Ripatti , Arpo Aromaa , Jouko Lonnqvist , Iiris Hovatta2,3,10 1 Work Organizations, Finnish Institute of Occupational Health, Helsinki, Finland, 2 Research Programs Unit – Molecular Neurology, University of Helsinki, Helsinki, Finland, 3 Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland, 4 Department of Epidemiology and Public Health, University College London, London, United Kingdom, 5 Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland, 6 Institute of Molecular Medicine Finland FIMM, Helsinki, Finland, 7 Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, 8 Department of Human Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 9 Public Health Consulting, Europe, Helsinki, Finland, 10 Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland, 11 Department of Psychiatry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland Abstract Background: Psychological stress is suggested to accelerate the rate of biological aging. We investigated whether work- related exhaustion, an indicator of prolonged work stress, is associated with accelerated biological aging, as indicated by shorter leukocyte telomeres, that is, the DNA-protein complexes that cap chromosomal ends in cells. Methods: We used data from a representative sample of the Finnish working-age population, the Health 2000 Study